Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Objective JAK inhibitor therapies are effective treatment options for immune‐mediated
inflammatory diseases (IMIDs), but their use has been limited by venous thromboembolism …

Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging
evidence suggests common mechanisms between cancer and cardiovascular disease …

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

ABSTRACT Introduction To date, four Janus kinase inhibitors (JAKis) are licensed for the
treatment of rheumatoid arthritis (RA) and/or psoriatic arthritis (PsA) in North America and/or …

Cardiometabolic disorders were originally thought to be driven primarily by changes in lipid
metabolism that cause the accumulation of lipids in organs, thereby impairing their function …

In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …