Multi-omics profiling for health

M Babu, M Snyder - Molecular & Cellular Proteomics, 2023 - ASBMB
The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

DNA sequencing at 40: past, present and future

J Shendure, S Balasubramanian, GM Church… - Nature, 2017 - nature.com
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …

[HTML][HTML] Long walk to genomics: History and current approaches to genome sequencing and assembly

AM Giani, GR Gallo, L Gianfranceschi… - Computational and …, 2020 - Elsevier
Genomes represent the starting point of genetic studies. Since the discovery of DNA
structure, scientists have devoted great efforts to determine their sequence in an exact way …

Analysis of RNA-Seq data using TopHat and Cufflinks

S Ghosh, CKK Chan - Plant Bioinformatics: Methods and Protocols, 2016 - Springer
The recent advances in high throughput RNA sequencing (RNA-Seq) have generated huge
amounts of data in a very short span of time for a single sample. These data have required …

Cancer transcriptome profiling at the juncture of clinical translation

M Cieślik, AM Chinnaiyan - Nature Reviews Genetics, 2018 - nature.com
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

Chemical ecology of endophytic fungi: origins of secondary metabolites

S Kusari, C Hertweck, M Spiteller - Chemistry & biology, 2012 - cell.com
Endophytes constitute a remarkably multifarious group of microorganisms ubiquitous in
plants and maintain an imperceptible association with their hosts for at least a part of their …

High-throughput transcriptome profiling in drug and biomarker discovery

X Yang, L Kui, M Tang, D Li, K Wei, W Chen… - Frontiers in …, 2020 - frontiersin.org
The development of new drugs is multidisciplinary and systematic work. High-throughput
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …

Gene expression profiling of plants under salt stress

A Jamil, S Riaz, M Ashraf, MR Foolad - Critical Reviews in Plant …, 2011 - Taylor & Francis
Soil salinity is among the leading environmental stresses affecting global agriculture,
causing billions of dollars in crop damages every year. Regardless of the cause, ion toxicity …

Transcriptomics technologies

R Lowe, N Shirley, M Bleackley, S Dolan… - PLoS computational …, 2017 - journals.plos.org
Transcriptomics technologies are the techniques used to study an organism's transcriptome,
the sum of all of its RNA transcripts. The information content of an organism is recorded in …

RNA-Seq: a revolutionary tool for transcriptomics

Z Wang, M Gerstein, M Snyder - Nature reviews genetics, 2009 - nature.com
RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-
sequencing technologies. Studies using this method have already altered our view of the …