Metastatic cancer is a major cause of death and remains largely incurable. A better
understanding of metastasis is therefore desperately needed to improve prognosis for late …

The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …

Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but
predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study …

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …

Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …

Melanoma is one of the most aggressive tumors of the skin, and its incidence is growing
worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic …

Metastatic melanoma carries a poor prognosis despite modern systemic therapies.
Understanding the evolution of the disease could help inform patient management. Through …

RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling.
We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling …

Cancer is an evolutionary process that is characterized by the emergence of multiple
genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity …

Simple Summary Melanoma is a skin cancer with a high mortality and a dramatically rising
presence worldwide. Recent research has shed new light on the genetic events that …