The growing medical need for tracheal replacement: reconstructive strategies should overcome their limits

D Adamo, G Galaverni, VG Genna, F Lococo… - … in Bioengineering and …, 2022 - frontiersin.org
Breathing, being predominantly an automatic action, is often taken for granted. However,
respiratory diseases affect millions of people globally, emerging as one of the major causes …

Tissue engineering applications in otolaryngology—The state of translation

WL Niermeyer, C Rodman, MM Li… - Laryngoscope …, 2020 - Wiley Online Library
While tissue engineering holds significant potential to address current limitations in
reconstructive surgery of the head and neck, few constructs have made their way into routine …

Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements

L Liu, S Dharmadhikari, BM Spector… - Journal of Tissue …, 2022 - journals.sagepub.com
We tested composite tracheal grafts (CTG) composed of a partially decellularized tracheal
graft (PDTG) combined with a 3-dimensional (3D)-printed airway splint for use in long …

Regeneration of partially decellularized tracheal scaffolds in a mouse model of orthotopic tracheal replacement

L Liu, S Dharmadhikari, KM Shontz… - Journal of Tissue …, 2021 - journals.sagepub.com
Decellularized tracheal scaffolds offer a potential solution for the repair of long-segment
tracheal defects. However, complete decellularization of trachea is complicated by tracheal …

Deconstructing tissue engineered trachea: assessing the role of synthetic scaffolds, segmental replacement and cell seeding on graft performance

S Dharmadhikari, L Liu, K Shontz, M Wiet, A White… - Acta biomaterialia, 2020 - Elsevier
The ideal construct for tracheal replacement remains elusive in the management of long
segment airway defects. Tissue engineered tracheal grafts (TETG) have been limited by the …

Tracheal macrophages during regeneration and repair of long‐segment airway defects

ZH Tan, S Dharmadhikari, L Liu, G Wolter… - The …, 2022 - Wiley Online Library
Objectives/Hypothesis Tissue‐engineered tracheal grafts (TETGs) offer a potential solution
for repair of long‐segment airway defects. However, preclinical and clinical TETGs have …

Assessing the Biocompatibility and Regeneration of Electrospun‐Nanofiber Composite Tracheal Grafts

L Kreber, L Liu, S Dharmadhikari, ZH Tan… - The …, 2024 - Wiley Online Library
Objective Composite tracheal grafts (CTG) combining decellularized scaffolds with external
biomaterial support have been shown to support host‐derived neotissue formation. In this …

Current status and future outlook of additive manufacturing technologies for the reconstruction of the trachea

HY Lee, JW Lee - Journal of Functional Biomaterials, 2023 - mdpi.com
Tracheal stenosis and defects occur congenitally and in patients who have undergone
tracheal intubation and tracheostomy due to long-term intensive care. Such issues may also …

Long‐Term Chondrocyte Retention in Partially Decellularized Tracheal Grafts

M Bergman, J Harwood, L Liu… - … –Head and Neck …, 2024 - Wiley Online Library
Objective Decellularized tracheal grafts possess the biological cues necessary for tissue
regeneration. However, conventional decellularization approaches to target the removal of …

A multimodal approach to quantify chondrocyte viability for airway tissue engineering

C Chan, L Liu, S Dharmadhikari, KM Shontz… - The …, 2023 - Wiley Online Library
Objectives/Hypothesis Partially decellularized tracheal scaffolds have emerged as a
potential solution for long‐segment tracheal defects. These grafts have exhibited …