The growing medical need for tracheal replacement: reconstructive strategies should overcome their limits
D Adamo, G Galaverni, VG Genna, F Lococo… - … in Bioengineering and …, 2022 - frontiersin.org
Breathing, being predominantly an automatic action, is often taken for granted. However,
respiratory diseases affect millions of people globally, emerging as one of the major causes …
respiratory diseases affect millions of people globally, emerging as one of the major causes …
Tissue engineering applications in otolaryngology—The state of translation
WL Niermeyer, C Rodman, MM Li… - Laryngoscope …, 2020 - Wiley Online Library
While tissue engineering holds significant potential to address current limitations in
reconstructive surgery of the head and neck, few constructs have made their way into routine …
reconstructive surgery of the head and neck, few constructs have made their way into routine …
Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements
L Liu, S Dharmadhikari, BM Spector… - Journal of Tissue …, 2022 - journals.sagepub.com
We tested composite tracheal grafts (CTG) composed of a partially decellularized tracheal
graft (PDTG) combined with a 3-dimensional (3D)-printed airway splint for use in long …
graft (PDTG) combined with a 3-dimensional (3D)-printed airway splint for use in long …
Regeneration of partially decellularized tracheal scaffolds in a mouse model of orthotopic tracheal replacement
L Liu, S Dharmadhikari, KM Shontz… - Journal of Tissue …, 2021 - journals.sagepub.com
Decellularized tracheal scaffolds offer a potential solution for the repair of long-segment
tracheal defects. However, complete decellularization of trachea is complicated by tracheal …
tracheal defects. However, complete decellularization of trachea is complicated by tracheal …
Deconstructing tissue engineered trachea: assessing the role of synthetic scaffolds, segmental replacement and cell seeding on graft performance
S Dharmadhikari, L Liu, K Shontz, M Wiet, A White… - Acta biomaterialia, 2020 - Elsevier
The ideal construct for tracheal replacement remains elusive in the management of long
segment airway defects. Tissue engineered tracheal grafts (TETG) have been limited by the …
segment airway defects. Tissue engineered tracheal grafts (TETG) have been limited by the …
Tracheal macrophages during regeneration and repair of long‐segment airway defects
Objectives/Hypothesis Tissue‐engineered tracheal grafts (TETGs) offer a potential solution
for repair of long‐segment airway defects. However, preclinical and clinical TETGs have …
for repair of long‐segment airway defects. However, preclinical and clinical TETGs have …
Assessing the Biocompatibility and Regeneration of Electrospun‐Nanofiber Composite Tracheal Grafts
Objective Composite tracheal grafts (CTG) combining decellularized scaffolds with external
biomaterial support have been shown to support host‐derived neotissue formation. In this …
biomaterial support have been shown to support host‐derived neotissue formation. In this …
Current status and future outlook of additive manufacturing technologies for the reconstruction of the trachea
HY Lee, JW Lee - Journal of Functional Biomaterials, 2023 - mdpi.com
Tracheal stenosis and defects occur congenitally and in patients who have undergone
tracheal intubation and tracheostomy due to long-term intensive care. Such issues may also …
tracheal intubation and tracheostomy due to long-term intensive care. Such issues may also …
Long‐Term Chondrocyte Retention in Partially Decellularized Tracheal Grafts
M Bergman, J Harwood, L Liu… - … –Head and Neck …, 2024 - Wiley Online Library
Objective Decellularized tracheal grafts possess the biological cues necessary for tissue
regeneration. However, conventional decellularization approaches to target the removal of …
regeneration. However, conventional decellularization approaches to target the removal of …
A multimodal approach to quantify chondrocyte viability for airway tissue engineering
C Chan, L Liu, S Dharmadhikari, KM Shontz… - The …, 2023 - Wiley Online Library
Objectives/Hypothesis Partially decellularized tracheal scaffolds have emerged as a
potential solution for long‐segment tracheal defects. These grafts have exhibited …
potential solution for long‐segment tracheal defects. These grafts have exhibited …