The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …

Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

The Notch signaling pathway is evolutionarily conserved and responsible for cell fate
determination in the developing embryo and mature tissue. At the molecular level, ligand …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Small cell lung cancer (SCLC) is one of the four major histological types of lung cancer. The
incidence of SCLC in developed countries has declined in recent years, presumably …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

Abstract γ‐Secretase inhibitors (GSI s) are being actively repurposed as cancer therapeutics
based on the premise that inhibition of NOTCH 1 signaling in select cancers is therapeutic …

Over the past two decades, the Notch signaling pathway has been investigated as a
therapeutic target for the treatment of cancers, and more recently in the context of immune …