The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

Cellular differentiation, mating, and filamentous growth are regulated in many fungi by
environmental and nutritional signals. For example, in response to nitrogen limitation …

Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

Fungal secondary metabolites are of intense interest to humankind due to their
pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past decade …

Eukaryotic cells possess an exquisitely interwoven and fine-tuned series of signal
transduction mechanisms with which to sense and respond to the ubiquitous fermentable …

Glucose has dramatic effects on the regulation of carbon metabolism and on many other
properties of yeast cells. Several sensing and signalling pathways are involved. For many …

The preferred source of carbon and energy for yeast cells is glucose. When yeast cells are
grown in liquid cultures, they metabolize glucose predominantly by glycolysis, releasing …

Cells of all living organisms contain complex signal transduction networks to ensure that a
wide range of physiological properties are properly adapted to the environmental conditions …

Glucose not only serves as a nutrient but also exerts many hormone-like regulatory effects in
a wide variety of eukaryotic cell types. Recently, interest in identifying general mechanisms …