Exposure to hepatotoxic chemicals is involved in liver disease–related morbidity and
mortality worldwide. The liver responds to damage by triggering compensatory hepatic …

The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to
maximize bone matrix output. Nmp4 encodes a novel transcription factor that regulates bone …

The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on
human and fish health are well characterized and several lines of evidence suggest that …

In the mammalian heart, fetal cardiomyocytes proliferate prior to birth; however, they exit the
cell cycle shortly after birth. Recent studies show that adult cardiomyocytes re-enters the cell …

Arsenic is a well-known human carcinogen whose environmental exposure via drinking
water, food, and air impacts millions of people across the globe. Various mechanisms of …

Background Hepatocellular carcinoma (HCC) is the most common type of cancer and
causes a significant number of cancer-related deaths worldwide. The molecular …

The purpose of this doctoral work is to elucidate the genetic and molecular mechanisms of
inorganic arsenic (iAs) induced liver disease, with specific focus on how arsenite (+ 3 …

Nascent ZAAT polypeptides typically undergo one of three fates following synthesis in the
ER:(1) correctly folded protein is transported to the Golgi apparatus for secretion;(2) …

Endoplasmic reticulum (ER) stress is implicated in the etiologies of several chronic liver
diseases. Upon ER stress, the unfolded protein response (UPR) is activated, and regulates …