Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …

The ocean occupies three-fourths of the Earth's surface and hosts approximately 80% of all
living species. In fact, some areas of the sea such as coral reefs possess a biodiversity …

There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various
research groups have reported their role in different types of cancer. The X-ray structures of …

Aim To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest …

Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle.
However it is well established that monomeric CDK2 lacks regulatory activity, which needs …

Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can
effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse …

Simple Summary By combining drug screens, transcriptomic studies, and in vitro assays, our
study identified the natural product toyocamycin as a potent and selective CDK9 inhibitor …

Cancer continues to be a major public health problem despite the efforts that have been
made in the search for novel drugs and treatments. The current sources sought for the …