The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The background knowledge leading to the isolation and identification of anandamide and 2-
arachidonoyl glycerol, the principal endocannabinoids is described. The structure–activity …

Serotonin is a major component of the inflammatory chemical milieu and contributes to the
pain of tissue injury via an action on multiple receptor subtypes. Here we studied mice after …

The 5-HT3 receptor is a member of the Cys-loop family of ligand-gated ion channels. These
receptors are located in both the peripheral and central nervous systems, where functional …

The 5-HT3 receptor is a neurotransmitter-gated ion channel. It is a member of the Cys-loop
family of receptors, which also includes nicotinic acetylcholine, glycine and GABAA …

Rationale: The serotonin system has an important role in the modulation of several
processes relevant to psychiatry such as anxiety, affect, aggression, and drug abuse. This …

While homomers containing 5-HT 3A subunits form functional ligand-gated serotonin (5-HT)
receptors in heterologous expression systems (Jackson, MB, and Yakel, JL (1995) Annu …

5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic
agents, some of which have had a major impact on disease management. The 5-HT …