Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

The complete amino acid sequence of human insulin-like growth factor I (IGF-I), a
polypeptide isolated from serum, has been determined. IGF-I is a single chain polypeptide of …

The nucleotide sequence for the human nerve growth factor (NGF) receptor has been
determined. The 3.8 kb receptor mRNA encodes a 427 amino acid protein containing a 28 …

The systematic comparison of every newly determined amino acid sequence with all other
known sequences may allow a complete reconstruction of the evolutionary events leading to …

Diabetic polyneuropathy (DPN) continues to be generally considered as a “microvascular”
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …

Epidermal keratinocytes (skin cells) are highly specialized epithelial cells designed to
perform a very specific function, separation of the organism from its environment. To …

The gene family of neurotrophins includes nerve growth factor (NGF), brain‐derived
neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3), and neurotrophin‐4 (NT‐4). Recently …

The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla,
has become a premiere model for the study of neuronal differentiation. When treated in …

Cellular diversity in the nervous system evolves from the concerted processes of cell
proliferation, differentiation, migration, survival, and synapse formation. Neural adhesion …