The drug candidates coming from combinatorial chemistry research and/or the drugs
selected from biologically based high-throughput screening are quite often very lipophilic, as …

Introduction: Poor solubility and dissolution of drugs are the major challenges in drug
formulation and delivery. In order to improve the solubility and dissolution profile of drugs …

Cyclodextrins (CDs) are cyclic oligosaccharides composed of D-glucopyranoside units
linked by glycosidic bonds. Their main property is the ability to modify the physicochemical …

The current investigation was aimed to improve the solubility of poorly soluble lercanidipine
hydrochloride as self emulsifying powder (SEP). Liquid SEDDS of LCH was formulated with …

Co-solvent solubilization approach has been used to enhance the solubility of seven
antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and …

Glimepiride (GMP), an oral hypoglycemic agent is extensively employed in the treatment of
type 2 diabetes. Transdermal delivery of GMP has been widely investigated as a promising …

MATERIALS AND METHODS Pure samples of sulfonylureas and glitazones were obtained
as gift from M/s USV Pharmaceuticals Ltd., Solan, HP, India. Pure repaglinide was a …

The purpose of this study was to combine the advantages of self-nanoemulsifying drug
delivery systems and tablets as a conventional dosage form emphasizing the excipients' …

Fenofibrate (FE) has been shown to markedly reduce the progression of diabetic retinopathy
and age-related macular degeneration in clinical trials and animal models. Owing to the …

This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on
the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of …