Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Knowledge of the plasma selenium levels associated with optimised concentration or activity
of specific selenoproteins can provide considerable insights from epidemiological data on …

The discovery of multiple selenoproteins has raised tantalizing questions about their role in
maintaining normal cellular function. Unfortunately, many of these remain inadequately …

Background The oxidative modifications of bioactive macromolecules have important roles
in carcinogenesis. Of particular interest are lipid peroxidation products, which are involved in …

Selenium (Se) is an essential micronutrient that is incorporated into selenoproteins.
Although epidemiological studies suggest that low Se intake is associated with increased …

BACKGROUND: Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown
etiology. We studied the gene–environment interaction in the pathogenesis of KD by …

Selenoproteins comprise a unique class of proteins that contain selenium in the form of
selenocysteine. Several selenoproteins have been implicated in the risk or development of …

The potentially functional polymorphism Ser326Cys in the human 8-oxoguanine DNA
glycosylase (hOGG1) gene has been implicated in lung cancer risk, but published studies …

Antioxidant defence enzymes are essential protectors of living organisms against oxidative
stress. These enzymes are involved in the detoxification and decomposition of harmful …

Selenium has been proven to influence several biological functions, showing to be an
essential micronutrient. The functional studies demonstrated the benefits of a balanced …