Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras (G12S)
Drugs that directly impede the function of driver oncogenes offer exceptional efficacy and a
therapeutic window. The recently approved mutant selective small-molecule cysteine …
therapeutic window. The recently approved mutant selective small-molecule cysteine …
Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins
Z Zhang, KM Shokat - Angewandte Chemie, 2019 - Wiley Online Library
Here we report the design, synthesis, and characterization of bifunctional chemical ligands
that induce the association of Ras with ubiquitously expressed immunophilin proteins such …
that induce the association of Ras with ubiquitously expressed immunophilin proteins such …
GTP-state-selective cyclic peptide ligands of K-Ras (G12D) block its interaction with Raf
We report the identification of three cyclic peptide ligands of K-Ras (G12D) using an
integrated in vitro translation–mRNA display selection platform. These cyclic peptides show …
integrated in vitro translation–mRNA display selection platform. These cyclic peptides show …
RNA-aptamers that modulate the RhoGEF activity of Tiam1
B Niebel, CI Wosnitza, M Famulok - Bioorganic & medicinal chemistry, 2013 - Elsevier
Rho GTPases regulate the actin cytoskeleton and thereby control cell migration, cell
morphology, cell motility, and other cellular functions. The gene product of the oncogene …
morphology, cell motility, and other cellular functions. The gene product of the oncogene …
Nucleotides and nucleic acids; oligo-and poly-nucleotides
D Loakes - 2014 - books.rsc.org
The synthesis of modified oligonucleotides is, as in previous years, divided into sections
describing updates on synthesis, followed by modifications to the backbone, sugar and …
describing updates on synthesis, followed by modifications to the backbone, sugar and …