Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …

Proteases are a set of enzymes that have been involved in multiple biological processes
throughout evolution. Among them, extracellular matrix (ECM) remodeling has emerged as …

Repair following injury involves a range of processes–such as re-epithelialization, scar
formation, angiogenesis, inflammation, and more–that function, often together, to restore …

Fibrosis–a debilitating condition that can occur in most organs–is characterized by excess
deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Platelet rich plasma (PRP) is a powerful new biologic tool in sports medicine. PRP is a
fraction of autologous whole blood containing and increased number of platelets and a wide …

Skeletal muscle regeneration is a complex process, which is not yet completely understood.
Satellite cells, the skeletal muscle stem cells, become activated after trauma, proliferate, and …

Engineering complex tissues requires a precisely formulated combination of cells,
spatiotemporally released bioactive factors, and a specialized scaffold support system …

In response to skeletal muscle injury, distinct cellular pathways are activated to repair the
damaged tissue. Activation and restriction of these pathways must be temporally …