Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four
members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Zebrafish are an established research organism that has made many contributions to our
understanding of vertebrate tissue and organ development, yet there are still significant …

Abstract Background: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate
head organizer and induces anterior development by antagonizing Wnt signaling. Although …

WNT signalling has a key role in early embryonic patterning through the regulation of cell
fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling …

Abstract Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with
BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show …

Anteroposterior (AP) patterning of the vertebrate neural plate is initiated during gastrulation
and is regulated by Spemann's organizer and its derivatives. The prevailing model for AP …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Truncation of the tumour suppressor adenomatous polyposis coli (Apc) constitutively
activates the Wnt/β-catenin signalling pathway. Apc has a role in development: for example …