Role of the PE/PPE family in host–pathogen interactions and prospects for anti-tuberculosis vaccine and diagnostic tool design

J Qian, R Chen, H Wang, X Zhang - Frontiers in cellular and infection …, 2020 - frontiersin.org
The pe/ppe genes are found in pathogenic, slow-growing Mycobacterium tuberculosis and
other M. tuberculosis complex (MTBC) species. These genes are considered key factors in …

Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines

F Guo, J Wei, Y Song, B Li, Z Qian, X Wang… - Frontiers in …, 2023 - frontiersin.org
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis
(Mtb), and its incidence and mortality are increasing. The BCG vaccine was developed in the …

The Mycobacterium tuberculosis PE_PGRS Protein Family Acts as an Immunological Decoy to Subvert Host Immune Response

T Sharma, A Alam, A Ehtram, A Rani, S Grover… - International Journal of …, 2022 - mdpi.com
Mycobacterium tuberculosis (M. tb) is a successful pathogen that can reside within the
alveolar macrophages of the host and can survive in a latent stage. The pathogen has …

Rv3539 (PPE63) of Mycobacterium Tuberculosis Promotes Survival of Mycobacterium Smegmatis in Human Macrophages Cell Line via Cell Wall Modulation of …

PK Anand, J Kaur - Current Microbiology, 2023 - Springer
The modulation of host's immune response plays an important role in the intracellular
survival of Mycobacterium tuberculosis. The intracellular pathogen counteracts …

Cell wall and immune modulation by Rv1800 (PPE28) helps M. smegmatis to evade intracellular killing

PK Anand, V Saini, J Kaur, A Kumar, J Kaur - International Journal of …, 2023 - Elsevier
Rv1800 is predicted as PPE family protein found in pathogenic mycobacteria only. Under
acidic stress, the rv1800 gene was expressed in M. tuberculosis H37Ra. In-silico study …

Long-Term Immunogenicity and In Vitro Prophylactic Protective Efficacy of M. tuberculosis Fusion Protein DR2 Combined with Liposomal Adjuvant DIMQ as a …

L Mao, J Du, X Wang, L Xu, Y Zhang, Q Sun… - ACS Infectious …, 2023 - ACS Publications
The resuscitation of dormant Mycobacterium tuberculosis is an important cause of adult
tuberculosis (TB) transmission. According to the interaction mechanism between M …

Mycobacterium tuberculosis YrbE3A Promotes Host Innate Immune Response by Targeting NF-κB/JNK Signaling

J Wang, X Zhu, Y Peng, T Zhu, H Liu, Y Zhu, X Xiong… - Microorganisms, 2020 - mdpi.com
Mycobacterium tuberculosis is considered a successful pathogen with multiple strategies to
undermine host immunity. The YrbE3A is encoded by Rv1964 within the RD15 region …

The PE and PPE Family Proteins of Mycobacterium tuberculosis: What they Are Up To?

R Pal, F Nazar, S Mukhopadhyay - Mycobacterium tuberculosis: Molecular …, 2019 - Springer
An ebb and flow journey of over 125 years since the discovery of Mycobacterium
tuberculosis (M. tb), the causative agent of tuberculosis (TB), clearly established it as an …

Impact of the elderly lung mucosa on Mycobacterium tuberculosis metabolic adaptation during infection of alveolar epithelial cells

AM Olmo-Fontánez, A Allué-Guardia… - bioRxiv, 2024 - biorxiv.org
Background: Tuberculosis (TB) is one of the top leading causes of death due to a single
infectious agent. Upon infection, Mycobacterium tuberculosis (M. tb) is deposited in the …

[HTML][HTML] Identification and characterization of antigenic and immunomodulatory properties of PE and PPE proteins of Mycobacterium tuberculosis

M García Bengoa - 2023 - elib.tiho-hannover.de
Tuberkulose (TB) stellt nach wie vor eine erhebliche globale Gesundheitsbelastung dar, von
der jedes Jahr Millionen von Menschen betroffen sind und die zahlreiche Todesfälle …