Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a
range of neurodegenerative diseases. Tau filaments adopt different conformations in …

Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich
foods significantly improve cognitive capabilities, inhibit or delay the senescence process …

The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …