Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment.
Mitochondria are major consumers of oxygen and a potential source of reactive oxygen …

Lung cancer (LC) is the leading cause of cancer-related death worldwide and miRNAs play
a key role in LC development. To better diagnose LC and to predict drug treatment …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

ABSTRACT Hypoxia‐Inducible Factor‐1 (HIF‐1) has been largely studied for its role in cell
survival in hypoxic conditions. The regulation of HIF‐1 is a complex process and involves a …