Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the
research following this discovery focused on the role of leptin in body weight regulation …

The prevalence of obesity and related diabetes mellitus is increasing worldwide. Here we
review evidence for the existence of an adipoinsular axis, a dual hormonal feedback loop …

Much attention has focused on the effects of leptin as a central satiety agent. There is now a
significant amount of evidence that leptin is active in the periphery. This review focuses on …

The relative stability of body weight over the long term and under a variety of environmental
conditions that alter short-term energy intake and expenditure provides strong evidence for …

OBJECTIVE: To study clinical, anthropometric and metabolic determinants of serum leptin
concentrations in a series of patients with a wide range of obesity. SUBJECTS: 400 patients …

In vitro, leptin secretion is regulated at the level of mRNA translation by the rapamycin-
sensitive mammalian target of rapamycin (mTOR) and its agonist leucine (Leu). Studies …

The increasing prevalence of obesity, particularly in developing countries is a major health
concern due to the high risk factor that overweight and obesity represent in a number of …

Food deprivation (FD) increases hypothalamic neuropeptide Y (NPY) and agouti-related
protein (AGRP) mRNA levels and decreases proopiomelanocortin (POMC) mRNA levels; …

Insulin detemir (Levemir®, Novo Nordisk) is a novel, biologically engineered analogue of
human insulin that has been successfully developed for clinical use in diabetes as a basal …

Leptin administered (either intracerebroventricularly, icv, or intraperitoneally, ip) acts in
synergy with CCK to suppress food intake and body weight in lean mice or rats. The …