The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
[HTML][HTML] AlphaFold and implications for intrinsically disordered proteins
Accurate predictions of the three-dimensional structures of proteins from their amino acid
sequences have come of age. AlphaFold, a deep learning-based approach to protein …
sequences have come of age. AlphaFold, a deep learning-based approach to protein …
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse - Emerging topics in life sciences, 2020 - europepmc.org
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure
Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …
proteomes in which they play a wide variety of essential roles. A critical first step in …
Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
Sequence grammar underlying the unfolding and phase separation of globular proteins
Aberrant phase separation of globular proteins is associated with many diseases. Here, we
use a model protein system to understand how the unfolded states of globular proteins drive …
use a model protein system to understand how the unfolded states of globular proteins drive …
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
CA Elena-Real, A Sagar, A Urbanek… - Nature structural & …, 2023 - nature.com
Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …
Connecting coil-to-globule transitions to full phase diagrams for intrinsically disordered proteins
Phase separation is thought to underlie spatial and temporal organization that is required for
controlling biochemical reactions in cells. Multivalence of interaction motifs, also known as …
controlling biochemical reactions in cells. Multivalence of interaction motifs, also known as …
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
T Kandola, S Venkatesan, J Zhang, BT Lerbakken… - Elife, 2023 - elifesciences.org
A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …
Therapeutics—how to treat phase separation-associated diseases
RJ Wheeler - Emerging Topics in Life Sciences, 2020 - portlandpress.com
Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …
associated proteins are able to form liquid membraneless compartments (condensates) by …