Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

In single-cell analysis, cellular activity and parameters are assayed on an individual, rather
than population-average basis. Essential to observing the activity of these cells over time is …

Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy
data, typically requiring human oversight and curation, which limit both accuracy and …

Protein activity is the ultimate arbiter of function in most cellular pathways, and protein
concentration is fundamentally connected to protein action. While the proteome of yeast has …

Existing computational pipelines for quantitative analysis of high‐content microscopy data
rely on traditional machine learning approaches that fail to accurately classify more than a …

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1
(mTORC1), which functions both as a nutrient sensor and a master controller of virtually all …

Proteomics has proved invaluable in generating large-scale quantitative data; however, the
development of systems approaches for examining the proteome in vivo has lagged behind …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

In recent years, microbioreactor (MBR) systems have evolved towards versatile bioprocess
engineering tools. They provide a unique solution to combine higher experimental …