This review comprises issues concerning cysteine cathepsins (CCs): human peptidases
belonging to papain family (C1) of clan CA of cysteine proteases: cathepsins B, L, H, S, K, F …

Cancer development is essentially a tissue remodeling process in which normal tissue is
substituted with cancer tissue. A crucial role in this process is attributed to proteolytic …

Purpose: Prognostic and predictive impact of five proteolytic factors associated with tumor
invasion and metastasis in primary breast cancer were evaluated after long-term follow-up …

Background The urokinase plasminogen activation (uPA) system is a crucial pathway for
tumour invasion and establishment of metastasis. Although there is good evidence that uPA …

Cathepsin D is a lysosomal acid proteinase which is involved in the malignant progression
of breast cancer and other gynecological tumors. Clinical investigations have shown that in …

Abstract Cyclooxygenase-2 (COX-2) is an important factor in gastric carcinogenesis, and
COX-2 expression in gastric cancer patients correlates with prognosis. We have now studied …

Background Serine/arginine-rich splicing factors (SRSFs) and HNRNPA1 have oncogenic
properties. However, their proteomic expressions and practical priority in gastric cancer (GC) …

Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different
physiological processes and signaling pathways, is accountable for metabolic breakdown of …

New tumor targeting agents are required to advance cancer diagnosis and treatment.
Bacteriophage (phage) display technology, a molecular genetic means of combinatorial …

To evaluate the possible role of cysteine proteases and serine proteases, as well as their
respective inhibitors and receptors, as new prognostic factors in NSCLC, we examined, for …