With the increasing number of options for the treatment of moderate‐to‐severe atopic
dermatitis, clinicians need guidance on a practical approach to selecting a systemic agent …

Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …

Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical
manifestations and molecular profiles. It is increasingly recognized that AD is a systemic …

Background Dupilumab, a monoclonal anti‐IL‐4Rα antibody, is approved for several type 2
mediated inflammatory diseases like asthma, atopic dermatitis, and diffuse type 2 chronic …

abstract The activation of group 2 innate lymphoid cells (ILC2s) is controlled by various
tissue-derived factors, including cytokines, whereas T cells respond to foreign antigens. This …

Innate lymphoid cells (ILCs) are innate lymphocytes that do not express antigen-specific
receptors and largely reside and self-renew in mucosal tissues. ILCs can be categorized into …

Single-cell RNA sequencing (scRNA-seq) is a novel technology that characterizes
molecular heterogeneity at the single-cell level. With the development of more automated …

Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …

Since atopic dermatitis (AD) is a heterogeneous condition, the subtyping of AD is a crucial
issue. The classical subtypes of AD are represented by extrinsic and intrinsic subtypes …

Objective Asthma is a chronic lung disease comprising multiple endotypes and
characterized by periodic exacerbations. A diverse array of T cells has been found to …