Abstract Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene
that plays an important regulatory role in detoxification, anti‑oxidative damage, and the …

Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular
metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) …

Objectives Cisplatin is the key systemic chemotherapeutic agent used for bladder cancer,
but chemoresistance is a major clinical problem. The transcription factor nuclear factor …

Exposure to potential carcinogens is an etiologic factor for renal cell carcinoma (RCC) and
transitional cell carcinoma (TCC) of the urinary bladder. Cytosolic glutathione S-transferases …

Cisplatin-based chemotherapy has been used for more than four decades as a standard
therapeutic option in several tumor entities. However, being a multifaceted and …

OBJECTIVES: Urothelial carcinoma of bladder is the second most common urological
malignancy after prostate cancer. Recently, there has been increased interest in research of …

OBJECTIVE:: We previously demonstrated that miR-133a is a tumor-suppressive microRNA
(miRNA) and is commonly down-regulated in human bladder cancer (BC). The aim of this …

Abstract Objectives Glutathione S-transferases (GSTs) are a family of enzymes involved in
detoxification. Genes encoding for GSTA1, GSTM1, GSTP1, and GSTT1 proteins are …

After protracted low level arsenic exposure, the normal human prostate epithelial cell line
RWPE-1 acquires a malignant phenotype with DNA hypomethylation, indicative of disrupted …

Abstract Background Hydrogen sulfide (H 2 S) is a newly discovered gas transmitter. It is
synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3 …