Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Dysregulated extravillous trophoblast invasion and proliferation are known to increase the
risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains …

Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The
cellular response to HIF activation is transcriptional upregulation of a large group of genes …

BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Development of the early embryo takes place under low oxygen tension. Under such
conditions, the embryo implants and the trophectoderm, the outer layer of blastocyst …

The placenta provides critical transport functions between the maternal and fetal circulations
during intrauterine development. Formation of this interface relies on coordinated …

Hemochorial placentation is orchestrated through highly regulated temporal and spatial
decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell …