Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives

S Ma, Y Leng, X Li, Y Meng, Z Yin, W Hang - TrAC Trends in Analytical …, 2023 - Elsevier
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

H Zhang, Y Liu, L Fields, X Shi, P Huang, H Lu… - Nature …, 2023 - nature.com
Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-
cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual …

Advances in MALDI mass spectrometry imaging single cell and tissues

X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Native mass spectrometry imaging of proteins and protein complexes by nano-DESI

OJ Hale, HJ Cooper - Analytical chemistry, 2021 - ACS Publications
Previously, we have demonstrated native mass spectrometry imaging (native MSI) in which
the spatial distribution of proteins maintained in their native-like, folded conformations was …

Recent advances in proteomics and metabolomics in plants

S Yan, R Bhawal, Z Yin, TW Thannhauser… - Molecular Horticulture, 2022 - Springer
Over the past decade, systems biology and plant-omics have increasingly become the main
stream in plant biology research. New developments in mass spectrometry and …

Tandem mass spectrometry imaging enables high definition for mapping lipids in tissues

X Guo, W Cao, X Fan, Z Guo, D Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) of lipids in biological tissues is useful for correlating
molecular distribution with pathological results, which could provide useful information for …

Microlensed fiber allows subcellular imaging by laser-based mass spectrometry

Y Meng, W Hang, RN Zare - Nature Protocols, 2023 - nature.com
Mass spectrometry imaging (MSI) enables the chemical mapping of molecules and elements
in a label-free, high-throughput manner. Because this approach can be accomplished …

Nanoscale three-dimensional imaging of drug distributions in single cells via laser desorption post-ionization mass spectrometry

X Li, L Hang, T Wang, Y Leng, H Zhang… - Journal of the …, 2021 - ACS Publications
Exploring the three-dimensional (3D) drug distribution within a single cell at nanoscale
resolution with mass spectrometry imaging (MSI) techniques is crucial in cellular biology, yet …

Single-cell mass spectrometry imaging of multiple drugs and nanomaterials at organelle level

Y Meng, C Gao, Q Lu, S Ma, W Hang - Acs Nano, 2021 - ACS Publications
Mass spectrometry imaging (MSI) techniques make possible the spatial chemical
identification of analytes, especially for biological samples. As a universal energy source …