Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

Insulin is a peptide hormone known for chiefly regulating glucose level in blood among
several other metabolic processes. Insulin remains the most effective drug for treating …

Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …

Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

The aggregation of insulin into amyloid fibers has been a limiting factor in the development
of fast acting insulin analogues, creating a demand for excipients that limit aggregation …

Amyloidosis is the major cause of many neurodegenerative diseases, such as, Alzheimer's
and Parkinson's where the misfolding and deposition of a previously functional protein make …

The self-assembly of insulin to form amyloid fibrils has been widely studied because it is a
significant problem in the medical management of diabetes and is an important model …

The discovery of insulin came with very high hopes for diabetic patients. In 2021, the world
celebrated the 100th anniversary of the discovery of this vital hormone. However, external …

Because the process of insulin fibril assembly is linked to a multitude of medical problems,
finding effective and biocompatible inhibitors against such an aggregation process could be …

Insulin-induced amyloidosis, a typical example of protein fibrillation, reduces the
effectiveness of insulin treatment in type-II diabetic patients, which demands intense …