DNA sequencing by synthesis using modified nucleotides and nanopore detection
US10443096B2 - DNA sequencing by synthesis using modified nucleotides and nanopore
detection - Google Patents US10443096B2 - DNA sequencing by synthesis using modified …
detection - Google Patents US10443096B2 - DNA sequencing by synthesis using modified …
Chip set-up and high-accuracy nucleic acid sequencing
R Davis, R Chen, A Bibillo, K Deierling - US Patent 9,494,554, 2016 - Google Patents
The present disclosure provides devices, systems and meth ods for sequencing nucleic acid
molecules. Nucleic acid molecules can be sequenced with a high accuracy (eg, greater than …
molecules. Nucleic acid molecules can be sequenced with a high accuracy (eg, greater than …
Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores
JG Mandell, KL Gunderson, JH Gundlach - US Patent 9,708,655, 2017 - Google Patents
0* P (= O)([O-]) OP (= O)([O-]) OP (= O)([O-]) OCC1OC (N2C= NC3= C2N= CN= C3N) C (O)
C1O. C# CC# CC# CC# CC= C. CC1= CC= C (N=[N+]=[N-]) C= C1 Chemical compound* P …
C1O. C# CC# CC# CC# CC= C. CC1= CC= C (N=[N+]=[N-]) C= C1 Chemical compound* P …
Nucleic acid sequencing by nanopore detection of tag molecules
J Ju, R Davis, R Chen - US Patent 11,608,523, 2023 - Google Patents
2017-10-12 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Nanopore-based single molecule characterization
RW Davis, RJA Chen - US Patent 9,121,059, 2015 - Google Patents
2,656,508 A 10, 1953 Coulter 4,121,192 A 10, 1978 Wilson 4,859,945 A 8, 1989 Stokar 5,
198,543 A 3, 1993 Blanco et al. 5,302,509 A 4, 1994 Cheeseman 5,308,539 A 5, 1994 …
198,543 A 3, 1993 Blanco et al. 5,302,509 A 4, 1994 Cheeseman 5,308,539 A 5, 1994 …
Recombinant polymerases for incorporation of protein shield nucleotide analogs
S Kamtekar, E Miller - US Patent 9,399,766, 2016 - Google Patents
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …
Pore-forming protein conjugate compositions and methods
J Ju, Z Li, S Kalachikov, C Fuller - US Patent 9,890,426, 2018 - Google Patents
2002/022883 3/2002 2002/029003 4/2002 2007/002204 1/2007 2007/053702 5/2007
2007/053719 5/2007 2007/146158 12/2007 2008/069973 6/2008 2009/051807 4/2009 …
2007/053719 5/2007 2007/146158 12/2007 2008/069973 6/2008 2009/051807 4/2009 …
Nanopore-based sequencing with varying voltage stimulus
RJA Chen, H Tian, B Maney - US Patent 9,557,294, 2017 - Google Patents
(57) ABSTRACT A method of analyzing a molecule in a nanopore is dis closed. A voltage is
applied across a nanopore that is inserted in a membrane by coupling the nanopore to a …
applied across a nanopore that is inserted in a membrane by coupling the nanopore to a …
Polymerase variants and uses thereof
A Aruna, C Arnold, CW Schwab, T Eileen… - US Patent …, 2020 - Google Patents
Described herein is a variant pol6 polymerase having at least one mutation selected from
H223, N224, Y225, H227, 1295, Y342, T343, 1357, S360, L361, 1363, S365, S366, Y367 …
H223, N224, Y225, H227, 1295, Y342, T343, 1357, S360, L361, 1363, S365, S366, Y367 …