Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …

Mitochondria contain two aqueous subcompartments, the matrix and the intermembrane
space (IMS). The matrix is enclosed by both the inner and outer mitochondrial membranes …

The mitochondrial inner membrane consists of two domains, inner boundary membrane and
cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Glutathione is an important mediator and regulator of cellular redox processes. Detailed
knowledge of local glutathione redox potential (EGSH) dynamics is critical to understand the …

Mitochondria, the powerhouses of the cell, import most of their proteins from the cytosol. It
was originally assumed that mitochondria imported precursor proteins via a general …

Mitochondrial precursor proteins are synthesized in the cytosol and subsequently imported
into mitochondria. The import of mitochondrial intermembrane space proteins is coupled …

Mitochondria are the central hub of key cellular processes such as energy conversion, cell
signaling, cell cycle regulation and cell differentiation. Therefore, in particular, mitochondrial …

The disulfide relay system in the intermembrane space of mitochondria is of crucial
importance for mitochondrial biogenesis. Major players in this pathway are the …

The mitochondrial intermembrane space hosts a machinery for oxidative protein folding, the
mitochondrial disulfide relay. This machinery imports a large number of soluble proteins into …