The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

The endoplasmic reticulum (ER) has a sophisticated quality control (QC) system to eliminate
improperly folded proteins from the secretory pathway. Given that protein folding is such a …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

The processing of N-linked glycans determines secretory protein homeostasis in the
eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) …

Asparagine-linked glycans (N-glycans) are displayed on the majority of proteins synthesized
in the endoplasmic reticulum (ER). Removal of the outermost glucose residue recruits the …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

As proteins travel through the endoplasmic reticulum (ER), a quality-control system retains
newly synthesized polypeptides and supports their maturation. Only properly folded proteins …