Bridging animal and human models of exercise-induced brain plasticity

MW Voss, C Vivar, AF Kramer, H van Praag - Trends in cognitive sciences, 2013 - cell.com
Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

The neuroprotective effects of exercise: maintaining a healthy brain throughout aging

LM Vecchio, Y Meng, K Xhima, N Lipsman… - Brain …, 2018 - content.iospress.com
Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Exercise benefits brain function: the monoamine connection

TW Lin, YM Kuo - Brain sciences, 2013 - mdpi.com
The beneficial effects of exercise on brain function have been demonstrated in animal
models and in a growing number of clinical studies on humans. There are multiple …

Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent …

AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

On the run for hippocampal plasticity

HY Moon, H van Praag - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Accumulating research in rodents and humans indicates that exercise benefits brain function
and may prevent or delay onset of neurodegenerative conditions. In particular, exercise …

Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity

TYC Pang, AJ Hannan - Neuropharmacology, 2013 - Elsevier
This review will provide an overview of the non-drug based approaches that have been
demonstrated to enhance cognitive function of the compromised brain, primarily focussed on …

Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

C Mo, AJ Hannan, T Renoir - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

The underestimated sex: A review on female animal models of depression

S Lima, N Sousa, P Patricio, L Pinto - Neuroscience & Biobehavioral …, 2022 - Elsevier
Major depression (MD) is the most common psychiatric disorder, predicted to affect around
264 million people worldwide. Although the etiology of depression remains elusive, the …