Obesity is a global epidemic characterized by energy disequilibrium, metabolic disorder, fat
mass development, and chronic low-grade inflammation, which significantly affects the …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Changes in microbial diversity and composition are increasingly associated with several
disease states including obesity and behavioural disorders. Obesity-associated microbiota …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Introduction Obesity is a major health problem that is associated with many physiological
and mental disorders, such as diabetes, stroke, and depression. Gut microbiota has been …

The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

In the past decade, emerging synthetic biology technologies such as chemogenetics have
dramatically transformed how pharmacologists and systems biologists deconstruct the …

Eating disorders (EDs) are serious psychiatric conditions influenced by biological,
psychological, and sociocultural factors. A better understanding of the genetics of these …

Background Lorcaserin is a selective serotonin 2C receptor agonist that could be useful in
reducing body weight. Methods In this double-blind clinical trial, we randomly assigned …