Cancer immunotherapy (CI) is rapidly advancing and can now be considered to be the “fifth
pillar” of cancer therapy, joining the ranks of surgery, cytotoxic chemotherapy, radiation, and …

Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

Over the past decades, microbiome research has evolved rapidly and became a hot topic in
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …

The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing
antigen receptors that are generated by somatic recombination, arose approximately 500 …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface
molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of …

Our insight into antitumour immune responses has increased considerably during the past
decades, yet the development of immunotherapy as a treatment modality for cancer has …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …