Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Ion channels are abundantly expressed in both excitable and non-excitable cells, thereby
regulating the Ca 2+ influx and downstream signaling pathways of physiological processes …

Targeting angiogenesis is considered a promising therapy for cancer. Besides curtailing
soluble factor mediated tumor angiogenesis, understanding the unexplored regulation of …

Transient Receptor Potential (TRP) channels modulate intracellular Ca2+ concentrations,
controlling critical cytosolic and nuclear events that are involved in the initiation and …

Intracellular Ca2+ signaling drives angiogenesis and vasculogenesis by stimulating
proliferation, migration, and tube formation in both vascular endothelial cells and endothelial …

Rather being an inert barrier between vessel lumen and surrounding tissues, vascular
endothelium plays a key role in the maintenance of cardiovascular homeostasis. The de …

Great efforts have been made to improve bone regeneration techniques owing to a growing
variety of sources of stem cells suitable for autologous transplants. Specifically, adipose …

The aim of this review is to address the recent advances regarding the use of
pharmacological agents to target transient receptor potential (TRP) channels in cancer and …

Introduction: Cancer is caused by defects in the mechanisms underlying cell proliferation,
death and migration. Calcium ions are central to all of these phenomena, serving as major …

The term “angiogenic switch” describes one of the earlier events of tumorigenesis, that
occurs when the balance between proand anti-angiogenic factors shifts towards a pro …