Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity
S Burma, BPC Chen, DJ Chen - DNA repair, 2006 - Elsevier
Of the various types of DNA damage that can occur within the mammalian cell, the DNA
double strand break (DSB) is perhaps the most dangerous. DSBs are typically induced by …
double strand break (DSB) is perhaps the most dangerous. DSBs are typically induced by …
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability
The list of long non-coding RNAs (lncRNAs) involved in the p53 pathway of the DNA
damage response is rapidly expanding, but whether lncRNAs have a role in maintaining the …
damage response is rapidly expanding, but whether lncRNAs have a role in maintaining the …
The role of BRCA1 in DNA damage response
J Wu, LY Lu, X Yu - Protein & cell, 2010 - Springer
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial
breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular …
breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular …
DNA damage and pulmonary hypertension
B Ranchoux, J Meloche, R Paulin, O Boucherat… - International journal of …, 2016 - mdpi.com
Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25
mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of …
mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of …
BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability
A Aly, S Ganesan - Journal of molecular cell biology, 2011 - academic.oup.com
BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated
DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of …
DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of …
[HTML][HTML] Overcoming chemoresistance in cancer: the promise of crizotinib
S Musa, N Amara, A Selawi, J Wang, C Marchini… - Cancers, 2024 - mdpi.com
Simple Summary Cancer cells often become resistant to treatment, making it harder to fight
the disease effectively. This resistance can happen due to genetic changes, proteins that …
the disease effectively. This resistance can happen due to genetic changes, proteins that …
Human DHX9 helicase unwinds triple-helical DNA structures
Naturally occurring poly (purine· pyrimidine) rich regions in the human genome are prone to
adopting non-canonical DNA structures such as intramolecular triplexes (ie, H-DNA). Such …
adopting non-canonical DNA structures such as intramolecular triplexes (ie, H-DNA). Such …
Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles
The basis of the conventional gene-centric view on tumor evolution is that vertically inherited
mutations largely define the properties of tumor cells. In recent years, however …
mutations largely define the properties of tumor cells. In recent years, however …