The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …

Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer,
metastasis formation and chemoresistance, and therefore represents an attractive target in …

Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …

Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and
the microenvironment are key determinants of the multistep process of tumor development …

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …