Extreme heterogeneity of human mitochondrial DNA from organelles to populations

JB Stewart, PF Chinnery - Nature Reviews Genetics, 2021 - nature.com
Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Mitochondrial DNA in innate immune responses and inflammatory pathology

AP West, GS Shadel - Nature Reviews Immunology, 2017 - nature.com
Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

AN Malik, A Czajka - Mitochondrion, 2013 - Elsevier
Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …

Guidelines for DNA taxonomy, with a focus on the meiofauna

D Fontaneto, JF Flot, CQ Tang - Marine Biodiversity, 2015 - Springer
Describing biological diversity is a challenging endeavour, especially for the small, cryptic
animals that make up the meiofauna. The field of DNA taxonomy, ie, the use of DNA to …

Mitochondrial diseases: a diagnostic revolution

KR Schon, T Ratnaike, J van den Ameele, R Horvath… - Trends in Genetics, 2020 - cell.com
Mitochondrial disorders have emerged as a common cause of inherited disease, but are
traditionally viewed as being difficult to diagnose clinically, and even more difficult to …

Molecular approaches to trematode systematics:'best practice'and implications for future study

I Blasco-Costa, SC Cutmore, TL Miller, MJ Nolan - Systematic parasitology, 2016 - Springer
To date, morphological analysis has been the cornerstone to trematode systematics.
However, since the late-1980s we have seen an increased integration of genetic data to …

Emerging role of mitochondrial DNA as a major driver of inflammation and disease progression

F Zhong, S Liang, Z Zhong - Trends in immunology, 2019 - cell.com
Inflammation benefits the host by promoting the elimination of invading pathogens and
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …

[HTML][HTML] The future of NGS (Next Generation Sequencing) analysis in testing food authenticity

E Haynes, E Jimenez, MA Pardo, SJ Helyar - Food control, 2019 - Elsevier
The authenticity of foodstuffs is an important issue for consumers, regulators, producers and
processors, as fraudulent practices can negatively affect consumer confidence and safety …

Molecular tools and analytical approaches for the characterization of farm animal genetic diversity

JA Lenstra, LF Groeneveld, H Eding… - Animal …, 2012 - Wiley Online Library
Genetic studies of livestock populations focus on questions of domestication, withinand
amongbreed diversity, breed history and adaptive variation. In this review, we describe the …

[PDF][PDF] A revolutionary protocol to describe understudied hyperdiverse taxa and overcome the taxonomic impediment

S Meierotto, MJ Sharkey, DH Janzen… - Deutsche …, 2019 - dez.pensoft.net
Here we elucidate and justify a DNA barcode approach to insect species description that
can be applied to name tens of thousands of species of Ichneumonoidea and many other …