Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

It is currently thought that immune responses are initiated by pathogen-associated molecular
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups …

▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

NKT cells represent a distinct lineage of T cells that coexpress a conserved αβ T cell
receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is …

Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

Sphingolipids and glycosphingolipids are membrane components of eukaryotic cell
surfaces. Their constitutive degradation takes place on the surface of intra-endosomal and …

Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …

Glycosylceramides in mammalian species are thought to be present in the form of β-
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …

The endosomal pathway of antigen presentation leads to the display of peptides on major
histocompatibility complex (MHC) class II molecules at the cell surface of antigen‐presenting …

The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …