Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction
Y Zhao, YH Chang, HR Ren, M Lou… - Journal of Agricultural …, 2024 - ACS Publications
Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively
used as a plasticizer to improve the plasticity of agricultural products, which pose severe …
used as a plasticizer to improve the plasticity of agricultural products, which pose severe …
The interface of mechanics and nociception in joint pathophysiology: insights from the facet and temporomandibular joints
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma.
Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and …
Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and …
[HTML][HTML] Materials science and mechanosensitivity of living matter
Living systems are composed of molecules that are synthesized by cells that use energy
sources within their surroundings to create fascinating materials that have mechanical …
sources within their surroundings to create fascinating materials that have mechanical …
Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways
CA Mariano, S Sattari, GO Ramirez, M Eskandari - Respiratory Research, 2023 - Springer
Background Common respiratory illnesses, such as emphysema and chronic obstructive
pulmonary disease, are characterized by connective tissue damage and remodeling. Two …
pulmonary disease, are characterized by connective tissue damage and remodeling. Two …
[HTML][HTML] Biaxial mechanical properties of the bronchial tree: Characterization of elasticity, extensibility, and energetics, including the effect of strain rate and …
Distal airways commonly obstruct in lung disease and despite their importance, their
mechanical properties are vastly underexplored. The lack of bronchial experiments restricts …
mechanical properties are vastly underexplored. The lack of bronchial experiments restricts …
Collagen organization in facet capsular ligaments varies with spinal region and with ligament deformation
The spinal facet capsular ligament (FCL) is primarily comprised of heterogeneous
arrangements of collagen fibers. This complex fibrous structure and its evolution under …
arrangements of collagen fibers. This complex fibrous structure and its evolution under …
Tissue loading and microstructure regulate the deformation of embedded nerve fibres: predictions from single-scale and multiscale simulations
V Zarei, S Zhang, BA Winkelstein… - Journal of the Royal …, 2017 - royalsocietypublishing.org
Excessive deformation of nerve fibres (axons) in the spinal facet capsular ligaments (FCLs)
can be a cause of pain. The axons are embedded in the fibrous extracellular matrix (ECM) of …
can be a cause of pain. The axons are embedded in the fibrous extracellular matrix (ECM) of …
Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model
JM Middendorf, ME Ita, BA Winkelstein… - … and modeling in …, 2021 - Springer
In innervated collagenous tissues, tissue scale loading may contribute to joint pain by
transmitting force through collagen fibers to the embedded mechanosensitive axons …
transmitting force through collagen fibers to the embedded mechanosensitive axons …
The physiological basis of cervical facet-mediated persistent pain: Basic science and clinical challenges
ME Ita, S Zhang, TP Holsgrove, S Kartha… - journal of orthopaedic & …, 2017 - jospt.org
Chronic neck pain is a common condition and a primary clinical symptom of whiplash and
other spinal injuries. Loading-induced neck injuries produce abnormal kinematics between …
other spinal injuries. Loading-induced neck injuries produce abnormal kinematics between …
[HTML][HTML] Strain-dependent dynamic re-alignment of collagen fibers in skeletal muscle extracellular matrix
RP Wohlgemuth, S Sriram, KE Henricson, DT Dinh… - Acta Biomaterialia, 2024 - Elsevier
Collagen fiber architecture within the skeletal muscle extracellular matrix (ECM) is significant
to passive muscle mechanics. While it is thought that collagen fibers re-orient themselves in …
to passive muscle mechanics. While it is thought that collagen fibers re-orient themselves in …