Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Y Zhao, YH Chang, HR Ren, M Lou… - Journal of Agricultural …, 2024 - ACS Publications
Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively
used as a plasticizer to improve the plasticity of agricultural products, which pose severe …

The interface of mechanics and nociception in joint pathophysiology: insights from the facet and temporomandibular joints

MM Sperry, ME Ita, S Kartha… - Journal of …, 2017 - asmedigitalcollection.asme.org
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma.
Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and …

[HTML][HTML] Materials science and mechanosensitivity of living matter

AE Patteson, ME Asp, PA Janmey - Applied Physics Reviews, 2022 - pubs.aip.org
Living systems are composed of molecules that are synthesized by cells that use energy
sources within their surroundings to create fascinating materials that have mechanical …

Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways

CA Mariano, S Sattari, GO Ramirez, M Eskandari - Respiratory Research, 2023 - Springer
Background Common respiratory illnesses, such as emphysema and chronic obstructive
pulmonary disease, are characterized by connective tissue damage and remodeling. Two …

[HTML][HTML] Biaxial mechanical properties of the bronchial tree: Characterization of elasticity, extensibility, and energetics, including the effect of strain rate and …

S Sattari, CA Mariano, M Eskandari - Acta Biomaterialia, 2023 - Elsevier
Distal airways commonly obstruct in lung disease and despite their importance, their
mechanical properties are vastly underexplored. The lack of bronchial experiments restricts …

Collagen organization in facet capsular ligaments varies with spinal region and with ligament deformation

E Ban, S Zhang, V Zarei… - Journal of …, 2017 - asmedigitalcollection.asme.org
The spinal facet capsular ligament (FCL) is primarily comprised of heterogeneous
arrangements of collagen fibers. This complex fibrous structure and its evolution under …

Tissue loading and microstructure regulate the deformation of embedded nerve fibres: predictions from single-scale and multiscale simulations

V Zarei, S Zhang, BA Winkelstein… - Journal of the Royal …, 2017 - royalsocietypublishing.org
Excessive deformation of nerve fibres (axons) in the spinal facet capsular ligaments (FCLs)
can be a cause of pain. The axons are embedded in the fibrous extracellular matrix (ECM) of …

Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model

JM Middendorf, ME Ita, BA Winkelstein… - … and modeling in …, 2021 - Springer
In innervated collagenous tissues, tissue scale loading may contribute to joint pain by
transmitting force through collagen fibers to the embedded mechanosensitive axons …

The physiological basis of cervical facet-mediated persistent pain: Basic science and clinical challenges

ME Ita, S Zhang, TP Holsgrove, S Kartha… - journal of orthopaedic & …, 2017 - jospt.org
Chronic neck pain is a common condition and a primary clinical symptom of whiplash and
other spinal injuries. Loading-induced neck injuries produce abnormal kinematics between …

[HTML][HTML] Strain-dependent dynamic re-alignment of collagen fibers in skeletal muscle extracellular matrix

RP Wohlgemuth, S Sriram, KE Henricson, DT Dinh… - Acta Biomaterialia, 2024 - Elsevier
Collagen fiber architecture within the skeletal muscle extracellular matrix (ECM) is significant
to passive muscle mechanics. While it is thought that collagen fibers re-orient themselves in …