The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …

The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

Cancer as a disease continues to ravage the world population without regard to sex, age,
and race. Due to the growing number of cases worldwide, cancer exerts a significant …

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton
organization, migration, transcription, and proliferation. A common theme of these processes …

Cancer cells undergo genetic changes allowing their adaptation to environmental changes,
thereby obtaining an advantage during the long metastatic route, disseminated of several …

According to a “canonical” view, reactive oxygen species (ROS) positively contribute, in
different ways, to carcinogenesis and to malignant progression of tumor cells: they drive …

Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on
apposed cell surfaces plays important roles in development and exhibits poorly understood …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Although the growth factor progranulin was discovered more than two decades ago, the
functional receptor remains elusive. Here, we discovered that EphA2, a member of the large …