ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a
hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its …

Epigenetic mechanisms play an important role in the development and persistence of
cancer, and histone deacetylase (HDAC) inhibitors are promising anticancer drugs targeting …

Background Although trimodality therapy resecting tumours followed by chemoradiotherapy
is emerged for muscle-invasive bladder cancer (MIBC), chemotherapy produces toxicities …

Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

N6‐methyladenosine (m6A) and its regulatory proteins have been associated with
tumorigenesis in several cancer types. However, knowledge on the mechanistic network …

Prostate cancer (PCa) is the second most common malignancy among men worldwide.
Although early-stage disease is curable, advanced stage PCa is mostly incurable and …

Simple Summary Although in the last decades the clinical outcome of cancer patients
considerably improved, the major drawbacks still associated with chemotherapy are the …

The Six Transmembrane Epithelial Antigen of the Prostate (STEAP1) is an oncogene
overexpressed in several human tumors, particularly in prostate cancer (PCa). However, the …