Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …

Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …

Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Recent research has established clear connections between G‐quadruplexes and human
disease. Features of quadruplex structures that promote genomic instability have been …

A cursory look at any textbook image of DNA replication might suggest that the complex
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …

G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four
guanines fold in a planar arrangement through Hoogsteen hydrogen bonds. Although many …