Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the
globe. They are mainly characterized by modified protein accumulation that might trigger …

Polyphenols are one of the most important metabolites in tea due to their unique biological
activities and health benefits, arousing great attention of researchers to investigate …

In recent years, neurological and neurodegenerative disorders research has focused on
altered molecular mechanisms in search of potential pharmacological targets, eg …

Down syndrome (DS) stands as the prevalent genetic cause of intellectual disability, yet
comprehensive understanding of its cellular and molecular underpinnings remains limited …

In the last decade, an important effort was made in the field of Down syndrome to find new
interventions that improve cognition. These therapies have added to the traditional …

Epigallocatechin gallate (EGCG) is the main bioactive component of green tea. Through
screening of a small library of natural compounds, we discovered that EGCG inhibits …

Introduction DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome
(DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive …

Septins are highly conserved GTP‐binding proteins that oligomerize and form higher order
structures. The septin cytoskeleton plays an important role in cellular organization …

Neurodevelopmental disorders arise from genetic and/or from environmental factors and are
characterized by different degrees of intellectual disability. The mechanisms that govern …

Sex differences in the composition and functionality of gut microbiota are an emerging field
of interest in neurodevelopmental disorders, as they may help in understanding the …