Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
The amyloid-β pathway in Alzheimer's disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Neuroprotection and disease modification by astrocytes and microglia in Parkinson disease
S Takahashi, K Mashima - Antioxidants, 2022 - mdpi.com
Oxidative stress and neuroinflammation are common bases for disease onset and
progression in many neurodegenerative diseases. In Parkinson disease, which is …
progression in many neurodegenerative diseases. In Parkinson disease, which is …
Functional networks in prolonged disorders of consciousness
H Li, X Zhang, X Sun, L Dong, H Lu, S Yue… - Frontiers in …, 2023 - frontiersin.org
Prolonged disorders of consciousness (DoC) are characterized by extended disruptions of
brain activities that sustain wakefulness and awareness and are caused by various …
brain activities that sustain wakefulness and awareness and are caused by various …
Gamma frequency sensory stimulation in probable mild Alzheimer's dementia patients: results of a preliminary clinical trial
Abstract Non-invasive Gamma ENtrainment Using Sensory stimuli (GENUS) at 40Hz
reduced Alzheimer's disease (AD) pathology, prevented cerebral atrophy and improved …
reduced Alzheimer's disease (AD) pathology, prevented cerebral atrophy and improved …
Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome
DJ Whiteside, D Street, AG Murley… - Human Brain …, 2023 - Wiley Online Library
There is a pressing need to understand the factors that predict prognosis in progressive
supranuclear palsy (PSP) and corticobasal syndrome (CBS), with high heterogeneity over …
supranuclear palsy (PSP) and corticobasal syndrome (CBS), with high heterogeneity over …
Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer's amyloid pathology
AA Stepanchuk, ML Morgan, JT Joseph… - Acta Neuropathologica …, 2022 - Springer
Protein misfolding is a prominent pathological hallmark of neurodegenerative disorders,
including Alzheimer's disease (AD). Studies have shown that the diversity of β sheet-rich …
including Alzheimer's disease (AD). Studies have shown that the diversity of β sheet-rich …
Machine learning based on functional and structural connectivity in mild cognitive impairment
Y Li, Y Shao, J Wang, Y Liu, Y Yang, Z Wang… - Magnetic Resonance …, 2024 - Elsevier
Objective Alzheimer's disease (AD) is a chronic, degenerative neurological disorder
characterized by progressive cognitive decline and mental behavioral abnormalities. Mild …
characterized by progressive cognitive decline and mental behavioral abnormalities. Mild …
40Hz sensory stimulation induces gamma entrainment and affects brain structure, sleep and cognition in patients with Alzheimer's dementia
Non-invasive G amma EN trainment U sing S ensory stimulation (GENUS) at 40Hz reduced
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevented cerebral …
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevented cerebral …