Computational Modeling of Autonomic Nerve Stimulation: Vagus et al.

WM Grill, NA Pelot - Current Opinion in Biomedical Engineering, 2024 - Elsevier
Computational models of electrical stimulation, block and recording of autonomic nerves
enable analysis of mechanisms of action underlying neural responses and design of …

Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans

ED Musselman, NA Pelot, WM Grill - Journal of Neural …, 2023 - iopscience.iop.org
Objective. We demonstrated how automated simulations to characterize electrical nerve
thresholds, a recently published open-source software for modeling stimulation of peripheral …

[HTML][HTML] Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation

F Ciotti, R John, N Katic Secerovic, N Gozzi… - Nature …, 2024 - nature.com
Bioelectronic therapies modulating the vagus nerve are promising for cardiovascular,
inflammatory, and mental disorders. Clinical applications are however limited by side-effects …

[HTML][HTML] NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies

T Couppey, L Regnacq, R Giraud… - PLOS Computational …, 2024 - journals.plos.org
Electrical stimulation of peripheral nerves has been used in various pathological contexts for
rehabilitation purposes or to alleviate the symptoms of neuropathologies, thus improving the …

[HTML][HTML] Spinal evoked compound action potentials in rats with clinically relevant stimulation modalities

DL Cedeño, R Vallejo, CA Kelley, DC Platt… - … : Technology at the …, 2023 - Elsevier
Objectives Rats are commonly used for translational pain and spinal cord stimulation (SCS)
research. Although many SCS parameters are configured identically between rats and …

[HTML][HTML] Computational models of compound nerve action potentials: Efficient filter-based methods to quantify effects of tissue conductivities, conduction distance, and …

E Peña, NA Pelot, WM Grill - PLoS computational biology, 2024 - journals.plos.org
Background Peripheral nerve recordings can enhance the efficacy of neurostimulation
therapies by providing a feedback signal to adjust stimulation settings for greater efficacy or …

Fractal microelectrodes for more energy‐efficient cervical vagus nerve stimulation

J Lim, CD Eiber, A Sun, A Maples… - Advanced …, 2023 - Wiley Online Library
Vagus nerve stimulation (VNS) has the potential to treat various peripheral dysfunctions, but
the traditional cuff electrodes for VNS are susceptible to off‐target effects. Microelectrodes …

[HTML][HTML] A simple model considering spiking probability during extracellular axon stimulation

F Rattay, T Tanzer - PLoS One, 2022 - journals.plos.org
The spiking probability of an electrically stimulated axon as a function of stimulus amplitude
increases in a sigmoidal dependency from 0 to 1. However, most computer simulation …

[HTML][HTML] Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study

X Wang, Y Zhang, T Guo, S Wu, J Zhong… - Computers in Biology …, 2024 - Elsevier
Carbon nanotube (CNT) fiber electrodes have demonstrated exceptional spatial selectivity
and sustained reliability in the context of intrafascicular electrical stimulation, as evidenced …

Modulating individual axons and axonal populations in the peripheral nerve using transverse intrafascicular multichannel electrodes

Y Xie, P Qin, T Guo, A Al Abed… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. A transverse intrafascicular multichannel electrode (TIME) may offer advantages
over more conventional cuff electrodes including higher spatial selectivity and reduced …