Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

INTRODUCTION The inflammasomes and the complement system are traditionally viewed
as quintessential components of innate immunity required for the detection and elimination …

Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory
response, which is essential for the proper functioning of our immune system. When …

The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …

Inflammasomes are large cytosolic multiprotein complexes that assemble in response to
detection of infection-or stress-associated stimuli and lead to the activation of caspase-1 …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-
recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane …

Cytopenias are key prognostic indicators of life-threatening infection, contributing to
immunosuppression and mortality. Here we define a role for Caspase-1-dependent death …