Emerging roles and functional mechanisms of PIWI-interacting RNAs
X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
piRNA-guided genome defense: from biogenesis to silencing
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
PIWI-interacting RNA: its biogenesis and functions
YW Iwasaki, MC Siomi, H Siomi - Annual review of biochemistry, 2015 - annualreviews.org
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
mRNP granules: assembly, function, and connections with disease
JR Buchan - RNA biology, 2014 - Taylor & Francis
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
[HTML][HTML] Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
Drosophila Piwi-family proteins have been implicated in transposon control. Here, we
examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and …
examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and …
Posttranscriptional upregulation by microRNAs
S Vasudevan - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
MicroRNAs are small non‐coding RNA guide molecules that regulate gene expression via
association with effector complexes and sequence‐specific recognition of target sites on …
association with effector complexes and sequence‐specific recognition of target sites on …
The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila
Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads.
Their target specificity is defined by 23–30 nt PIWI interacting RNAs (piRNAs), which mostly …
Their target specificity is defined by 23–30 nt PIWI interacting RNAs (piRNAs), which mostly …
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers
A Heravi-Moussavi, MS Anglesio… - … England Journal of …, 2012 - Mass Medical Soc
Background Germline truncating mutations in DICER1, an endoribonuclease in the RNase
III family that is essential for processing microRNAs, have been observed in families with the …
III family that is essential for processing microRNAs, have been observed in families with the …
An epigenetic role for maternally inherited piRNAs in transposon silencing
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying
cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic …
cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic …
MicroRNAs: key regulators of stem cells
VK Gangaraju, H Lin - Nature reviews Molecular cell biology, 2009 - nature.com
The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated
cells. This unique property is controlled by dynamic interplays between extrinsic signalling …
cells. This unique property is controlled by dynamic interplays between extrinsic signalling …