The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Current challenges and opportunities in treating glioblastoma

A Shergalis, A Bankhead, U Luesakul… - Pharmacological …, 2018 - ASPET
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

RV Iozzo, L Schaefer - Matrix biology, 2015 - Elsevier
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Regenerative scar-free skin wound healing

M Monavarian, S Kader, S Moeinzadeh… - … Engineering Part B …, 2019 - liebertpub.com
Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

[HTML][HTML] The evolving relationship of wound healing and tumor stroma

DS Foster, RE Jones, RC Ransom, MT Longaker… - JCI insight, 2018 - ncbi.nlm.nih.gov
The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

Exercise-induced myokines and their effect on prostate cancer

JS Kim, DA Galvão, RU Newton, E Gray… - Nature Reviews …, 2021 - nature.com
Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

RV Iozzo, RD Sanderson - Journal of cellular and molecular …, 2011 - Wiley Online Library
Introduction• Perlecan: a pro‐angiogenic proteoglycan• Endorepellin, a C‐terminal fragment
of perlecan with anti‐angiogenic activity• Syndecans in cancer biology• Glypicans and the …

Proteoglycans remodeling in cancer: Underlying molecular mechanisms

AD Theocharis, NK Karamanos - Matrix Biology, 2019 - Elsevier
Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

[PDF][PDF] Genome‐wide molecular profiles of HCV‐induced dysplasia and hepatocellular carcinoma

E Wurmbach, Y Chen, G Khitrov, W Zhang… - …, 2007 - Wiley Online Library
Although HCC is the third‐leading cause of cancer‐related deaths worldwide, there is only
an elemental understanding of its molecular pathogenesis. In western countries, HCV …