Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Design and engineering of artificial metalloproteins: from de novo metal coordination to catalysis
Metalloproteins are essential to sustain life. Natural evolution optimized them for intricate
structural, regulatory and catalytic functions that cannot be fulfilled by either a protein or a …
structural, regulatory and catalytic functions that cannot be fulfilled by either a protein or a …
Copper‐Catalysed Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies
C Xu, H Zhang, S Lan, J Liu, S Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
Transition‐metal‐catalysed reactions of cyclic ethynylethylene carbonates have been
intensively studied because of their robustness in new bond formation and diversified …
intensively studied because of their robustness in new bond formation and diversified …
Symmetry-adapted synthesis of dicopper oxidases with divergent dioxygen reactivity
SM Jung, M Yang, WJ Song - Inorganic chemistry, 2022 - ACS Publications
Artificial metalloenzymes have fed our understanding of how inorganic reactivities emerge,
evolve, and diversify in protein environments. Herein, we created dinuclear copper oxidases …
evolve, and diversify in protein environments. Herein, we created dinuclear copper oxidases …
Design of artificial metalloenzymes with multiple inorganic elements: The more the merrier
SM Jung, J Lee, WJ Song - Journal of Inorganic Biochemistry, 2021 - Elsevier
A large fraction of metalloenzymes harbors multiple metal-centers that are electronically
and/or functionally arranged within their proteinaceous environments. To explore the …
and/or functionally arranged within their proteinaceous environments. To explore the …
基于非天然结构组件的人工酶设计与应用
袁飞燕， 于洋， 李春 - 合成生物学, 2020 - synbioj.cip.com.cn
人工酶是由人类设计得到的具有类似天然酶活性的催化剂. 人工酶设计可能成为天然酶研究的
补充, 揭示天然酶的催化机理, 实现天然酶尚未实现的作用. 酶由20 种天然氨基酸残基以及有限 …
补充, 揭示天然酶的催化机理, 实现天然酶尚未实现的作用. 酶由20 种天然氨基酸残基以及有限 …
Recent advances in tuning redox properties of electron transfer centers in metalloenzymes catalyzing the oxygen reduction reaction and H2 oxidation important for …
Current fuel cell catalysts for the oxygen reduction reaction (ORR) and H 2 oxidation use
precious metals and, for ORR, require high overpotentials. In contrast, metalloenzymes …
precious metals and, for ORR, require high overpotentials. In contrast, metalloenzymes …
Artificial enzyme designs and its application based on non-natural structural elements
Y Feiyan, YU Yang, LI Chun - Synthetic Biology Journal, 2020 - synbioj.cip.com.cn
Artificial enzymes are catalysts designed by humans beings with similar activities to those of
natural enzymes. The design of artificial enzymes may be a supplement for the study of …
natural enzymes. The design of artificial enzymes may be a supplement for the study of …