Clones are the fundamental building blocks of immune repertoires. The number of different
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …

B cell receptor (BCR) signaling is a central pathway promoting the survival and proliferation
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …

Elucidating how antigen exposure and selection shape the human antibody repertoire is
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …

Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the
neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the …

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …

The accurate structural modeling of B-and T-cell receptors is fundamental to gain a detailed
insight in the mechanisms underlying immunity and in developing new drugs and therapies …

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of small
mature-looking CD19+ CD23+ CD5+ B-cells that accumulate in the blood, bone marrow …

More and more antibody therapeutics are being approved every year, mainly due to their
high efficacy and antigen selectivity. However, it is still difficult to identify the antigen, and …

With the advent of next-generation sequencing, the mutational landscape of chronic
lymphocytic leukemia (CLL) was rapidly unraveled with the discovery of recurrently mutated …

Antibodies (or immunoglobulins) are crucial for defending organisms from pathogens, but
they are also key players in many medical, diagnostic and biotechnological applications …